| 1 | Janus Henderson Group Ltd. | $960M | 1 | | |
| 2 | FMR LLC | $958M | 1 | | |
| 3 | BlackRock, Inc. | $638M | 1 | | |
| 4 | VANGUARD PORTFOLIO MANAGEMENT LLC | $365M | 1 | | |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | $364M | 1 | | |
| 6 | WELLINGTON MANAGEMENT GROUP LLP | $326M | 1 | | |
| 7 | Paradigm Biocapital Advisors LP | $279M | 1 | | |
| 8 | STATE STREET CORP | $258M | 1 | | |
| 9 | Deep Track Capital, LP | $250M | 1 | | |
| 10 | WESTFIELD CAPITAL MANAGEMENT CO LP | $212M | 1 | | |
| 11 | GEODE CAPITAL MANAGEMENT, LLC | $186M | 1 | | |
| 12 | Kynam Capital Management, LP | $170M | 1 | | |
| 13 | D. E. Shaw & Co., Inc. | $167M | 1 | | |
| 14 | Caligan Partners LP | $120M | 1 | | |
| 15 | JENNISON ASSOCIATES LLC | $98.7M | 1 | | |
| 16 | Polar Capital Holdings Plc | $82.9M | 1 | | |
| 17 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $81.6M | 1 | | |
| 18 | MAVERICK CAPITAL LTD | $80.1M | 1 | | |
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | $79.8M | 1 | | |
| 20 | Pivotal bioVenture Partners Investment Advisor LLC | $79.8M | 1 | | |
| 21 | UBS Group AG | $77.7M | 1 | | |
| 22 | FARALLON CAPITAL MANAGEMENT, L.L.C. | $73.3M | 1 | | |
| 23 | BANK OF AMERICA CORP /DE/ | $70.7M | 1 | | |
| 24 | Bellevue Group AG | $69.2M | 1 | | |
| 25 | Assenagon Asset Management S.A. | $67.7M | 1 | | |
| 26 | NORTHERN TRUST CORP | $66.5M | 1 | | |
| 27 | Aberdeen Group plc | $56.9M | 1 | | |
| 28 | Eversept Partners, LP | $53.7M | 1 | | |
| 29 | Capital Research Global Investors | $53.0M | 1 | | |
| 30 | Novo Holdings A/S | $50.0M | 1 | | |
| 31 | VANGUARD FIDUCIARY TRUST CO | $48.9M | 1 | | |
| 32 | Saturn V Capital Management LP | $47.9M | 1 | | |
| 33 | MORGAN STANLEY | $42.8M | 1 | | |
| 34 | Pictet Asset Management Holding SA | $40.7M | 1 | | |
| 35 | Trails Edge Capital Partners, LP | $38.5M | 1 | | |
| 36 | Jones Hill Capital LP | $37.5M | 1 | | |
| 37 | Point72 Asset Management, L.P. | $36.1M | 1 | | |
| 38 | FEDERATED HERMES, INC. | $32.9M | 1 | | |
| 39 | BOOTHBAY FUND MANAGEMENT, LLC | $30.3M | 1 | | |
| 40 | BALYASNY ASSET MANAGEMENT L.P. | $29.9M | 1 | | |
| 41 | BROWN ADVISORY INC | $29.7M | 1 | | |
| 42 | VICTORY CAPITAL MANAGEMENT INC | $29.2M | 1 | | |
| 43 | Bank of New York Mellon Corp | $27.6M | 1 | | |
| 44 | FRANKLIN RESOURCES INC | $27.5M | 1 | | |
| 45 | Ensign Peak Advisors, Inc | $25.9M | 1 | | |
| 46 | Alyeska Investment Group, L.P. | $25.3M | 1 | | |
| 47 | Ikarian Capital, LLC | $24.9M | 1 | | |
| 48 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $23.9M | 1 | | |
| 49 | Soleus Capital Management, L.P. | $22.4M | 1 | | |
| 50 | DIMENSIONAL FUND ADVISORS LP | $21.8M | 1 | | |
| 51 | AMERICAN CENTURY COMPANIES INC | $20.7M | 1 | | |
| 52 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $20.3M | 1 | | |
| 53 | Boxer Capital Management, LLC | $18.9M | 1 | | |
| 54 | Nuveen, LLC | $18.6M | 1 | | |
| 55 | Elmind Capital, LP | $18.4M | 1 | | |
| 56 | Candriam S.C.A. | $18.3M | 1 | | |
| 57 | TD ASSET MANAGEMENT INC | $18.2M | 1 | | |
| 58 | Logos Global Management LP | $17.4M | 1 | | |
| 59 | DEUTSCHE BANK AG\ | $17.4M | 1 | | |
| 60 | Artisan Partners Limited Partnership | $17.3M | 1 | | |
| 61 | MILLENNIUM MANAGEMENT LLC | $17.1M | 1 | | |
| 62 | Rosalind Advisors, Inc. | $16.9M | 1 | | |
| 63 | Woodline Partners LP | $16.0M | 1 | | |
| 64 | ADAR1 Capital Management, LLC | $15.1M | 1 | | |
| 65 | JANE STREET GROUP, LLC | $14.7M | 1 | | |
| 66 | RAYMOND JAMES FINANCIAL INC | $14.6M | 1 | | |
| 67 | Spruce Street Capital LP | $14.3M | 1 | | |
| 68 | University of Wisconsin Foundation | $13.9M | 1 | | |
| 69 | Nantahala Capital Management, LLC | $13.9M | 1 | | |
| 70 | Swiss National Bank | $13.5M | 1 | | |
| 71 | Freestone Grove Partners LP | $13.1M | 1 | | |
| 72 | Invesco Ltd. | $10.7M | 1 | | |
| 73 | SEGALL BRYANT & HAMILL, LLC | $10.7M | 1 | | |
| 74 | RHUMBLINE ADVISERS | $9.2M | 1 | | |
| 75 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | $8.8M | 1 | | |
| 76 | Qube Research & Technologies Ltd | $8.4M | 1 | | |
| 77 | SILVERARC CAPITAL MANAGEMENT, LLC | $8.4M | 1 | | |
| 78 | Creative Planning | $8.1M | 1 | | |
| 79 | CITIGROUP INC | $7.7M | 1 | | |
| 80 | Seven Fleet Capital Management LP | $7.5M | 1 | | |
| 81 | Clearbridge Investments, LLC | $7.5M | 1 | | |
| 82 | ExodusPoint Capital Management, LP | $7.3M | 1 | | |
| 83 | HighVista Strategies LLC | $7.2M | 1 | | |
| 84 | NAN FUNG TRINITY (HK) Ltd | $7.1M | 1 | | |
| 85 | NEW YORK STATE COMMON RETIREMENT FUND | $7.0M | 1 | | |
| 86 | STEMPOINT CAPITAL LP | $6.9M | 1 | | |
| 87 | TWO SIGMA INVESTMENTS, LP | $6.5M | 1 | | |
| 88 | AMERIPRISE FINANCIAL INC | $6.4M | 1 | | |
| 89 | SUPERSTRING CAPITAL MANAGEMENT LP | $6.4M | 1 | | |
| 90 | VANGUARD ASSET MANAGEMENT, Ltd | $6.3M | 1 | | |
| 91 | ALLIANCEBERNSTEIN L.P. | $6.3M | 1 | | |
| 92 | WCM INVESTMENT MANAGEMENT, LLC | $6.2M | 1 | | |
| 93 | Cormorant Asset Management, LP | $5.8M | 1 | | |
| 94 | ENVESTNET ASSET MANAGEMENT INC | $5.7M | 1 | | |
| 95 | Legal & General Group Plc | $5.7M | 1 | | |
| 96 | NEXTBio Capital Management LP | $5.5M | 1 | | |
| 97 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | $5.0M | 1 | | |
| 98 | Rafferty Asset Management, LLC | $4.6M | 1 | | |
| 99 | SummitTX Capital, L.P. | $4.3M | 1 | | |
| 100 | Cinctive Capital Management LP | $4.3M | 1 | | |
| 101 | STATE OF WISCONSIN INVESTMENT BOARD | $4.2M | 1 | | |
| 102 | MetLife Investment Management, LLC | $3.9M | 1 | | |
| 103 | Universal- Beteiligungs- und Servicegesellschaft mbH | $3.9M | 1 | | |
| 104 | TWINBEECH CAPITAL LP | $3.8M | 1 | | |
| 105 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $3.7M | 1 | | |
| 106 | BANQUE PICTET & CIE SA | $3.6M | 1 | | |
| 107 | VOYA INVESTMENT MANAGEMENT LLC | $3.6M | 1 | | |
| 108 | Rock Springs Capital Management LP | $3.5M | 1 | | |
| 109 | PRUDENTIAL FINANCIAL INC | $3.4M | 1 | | |
| 110 | Ishara Investments LP | $3.3M | 1 | | |
| 111 | RENAISSANCE TECHNOLOGIES LLC | $3.2M | 1 | | |
| 112 | WELLS FARGO & COMPANY/MN | $3.1M | 1 | | |
| 113 | Vanguard Global Advisers, LLC | $3.0M | 1 | | |
| 114 | Walleye Capital LLC | $2.9M | 1 | | |
| 115 | Sofinnova Investments, Inc. | $2.9M | 1 | | |
| 116 | Burkehill Global Management, LP | $2.9M | 1 | | |
| 117 | Trexquant Investment LP | $2.9M | 1 | | |
| 118 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2.7M | 1 | | |
| 119 | LAZARD ASSET MANAGEMENT LLC | $2.7M | 1 | | |
| 120 | Zurcher Kantonalbank (Zurich Cantonalbank) | $2.6M | 1 | | |
| 121 | State of New Jersey Common Pension Fund D | $2.3M | 1 | | |
| 122 | ArrowMark Colorado Holdings LLC | $2.3M | 1 | | |
| 123 | GUGGENHEIM CAPITAL LLC | $2.2M | 1 | | |
| 124 | PROFUND ADVISORS LLC | $2.1M | 1 | | |
| 125 | READYSTATE ASSET MANAGEMENT LP | $2.1M | 1 | | |
| 126 | SEI INVESTMENTS CO | $1.9M | 1 | | |
| 127 | Arizona State Retirement System | $1.9M | 1 | | |
| 128 | BARCLAYS PLC | $1.9M | 1 | | |
| 129 | INTECH INVESTMENT MANAGEMENT LLC | $1.8M | 1 | | |
| 130 | Hudson Bay Capital Management LP | $1.8M | 1 | | |
| 131 | Vanguard Personalized Indexing Management, LLC | $1.7M | 1 | | |
| 132 | Vanguard Investments Australia, Ltd. | $1.7M | 1 | | |
| 133 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $1.6M | 1 | | |
| 134 | LPL Financial LLC | $1.6M | 1 | | |
| 135 | Pathstone Holdings, LLC | $1.6M | 1 | | |
| 136 | KLP KAPITALFORVALTNING AS | $1.5M | 1 | | |
| 137 | AQR CAPITAL MANAGEMENT LLC | $1.5M | 1 | | |
| 138 | Mirae Asset Global Investments Co., Ltd. | $1.5M | 1 | | |
| 139 | DIADEMA PARTNERS LP | $1.5M | 1 | | |
| 140 | Ghisallo Capital Management LLC | $1.5M | 1 | | |
| 141 | ProShare Advisors LLC | $1.4M | 1 | | |
| 142 | MARTINGALE ASSET MANAGEMENT L P | $1.4M | 1 | | |
| 143 | Progeny 3, Inc. | $1.4M | 1 | | |
| 144 | Quantinno Capital Management LP | $1.3M | 1 | | |
| 145 | CIBC WORLD MARKET INC. | $1.2M | 1 | | |
| 146 | Odyssean, LLC | $1.2M | 1 | | |
| 147 | DV Trading LLC | $1.2M | 1 | | |
| 148 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $1.2M | 1 | | |
| 149 | Man Group plc | $1.1M | 1 | | |
| 150 | DnB Asset Management AS | $1.1M | 1 | | |
| 151 | Financiere des Professionnels - Fonds d'investissement inc. | $1.1M | 1 | | |
| 152 | B. Metzler seel. Sohn & Co. AG | $1.0M | 1 | | |
| 153 | GILDER GAGNON HOWE & CO LLC | $998K | 1 | | |
| 154 | TEACHER RETIREMENT SYSTEM OF TEXAS | $886K | 1 | | |
| 155 | XTX Topco Ltd | $876K | 1 | | |
| 156 | CIBC Bancorp USA Inc. | $814K | 1 | | |
| 157 | Baird Financial Group, Inc. | $801K | 1 | | |
| 158 | Baker Avenue Asset Management, LP | $764K | 1 | | |
| 159 | Mariner, LLC | $754K | 1 | | |
| 160 | Amundi | $753K | 1 | | |
| 161 | Bridgewater Associates, LP | $750K | 1 | | |
| 162 | Tower Research Capital LLC (TRC) | $707K | 1 | | |
| 163 | CANADA PENSION PLAN INVESTMENT BOARD | $680K | 1 | | |
| 164 | Brevan Howard Capital Management LP | $677K | 1 | | |
| 165 | XPONANCE LLC | $662K | 1 | | |
| 166 | Ameritas Investment Partners, Inc. | $598K | 1 | | |
| 167 | E Fund Management Co., Ltd. | $587K | 1 | | |
| 168 | Rockefeller Capital Management L.P. | $574K | 1 | | |
| 169 | Empowered Funds, LLC | $563K | 1 | | |
| 170 | Marex Group Ltd | $558K | 1 | | |
| 171 | Cetera Investment Advisers | $558K | 1 | | |
| 172 | Vident Advisory, LLC | $552K | 1 | | |
| 173 | Brooklyn Investment Group | $544K | 1 | | |
| 174 | Daiwa Securities Group Inc. | $543K | 1 | | |
| 175 | OSAIC HOLDINGS, INC. | $515K | 1 | | |
| 176 | Avior Wealth Management, LLC | $502K | 1 | | |
| 177 | ROYAL BANK OF CANADA | $496K | 1 | | |
| 178 | Meeder Advisory Services, Inc. | $484K | 1 | | |
| 179 | VARCOV Co. | $484K | 1 | | |
| 180 | Sumitomo Mitsui Trust Group, Inc. | $426K | 1 | | |
| 181 | SIGNATUREFD, LLC | $414K | 1 | | |
| 182 | Allianz Asset Management GmbH | $413K | 1 | | |
| 183 | Quarry LP | $407K | 1 | | |
| 184 | Swiss Life Asset Management Ltd | $400K | 1 | | |
| 185 | Values First Advisors, Inc. | $385K | 1 | | |
| 186 | Marks Group Wealth Management, Inc | $381K | 1 | | |
| 187 | Allspring Global Investments Holdings, LLC | $378K | 1 | | |
| 188 | Abel Hall, LLC | $376K | 1 | | |
| 189 | Sanctuary Advisors, LLC | $364K | 1 | | |
| 190 | Virtus Investment Advisers, LLC | $356K | 1 | | |
| 191 | Dynamic Technology Lab Private Ltd | $355K | 1 | | |
| 192 | INCEPTIONR LLC | $334K | 1 | | |
| 193 | Atom Investors LP | $328K | 1 | | |
| 194 | Cerity Partners LLC | $327K | 1 | | |
| 195 | Voleon Capital Management LP | $310K | 1 | | |
| 196 | Persistent Asset Partners Ltd | $309K | 1 | | |
| 197 | PRINCIPAL FINANCIAL GROUP INC | $307K | 1 | | |
| 198 | Fieldview Capital Management, LLC | $284K | 1 | | |
| 199 | Blackstone Inc. | $264K | 1 | | |
| 200 | CIBC Asset Management Inc | $262K | 1 | | |
| 201 | M&T BANK CORP | $245K | 1 | | |
| 202 | TOCQUEVILLE ASSET MANAGEMENT L.P. | $244K | 1 | | |
| 203 | Callan Family Office, LLC | $243K | 1 | | |
| 204 | Sterling Capital Management LLC | $241K | 1 | | |
| 205 | Headlands Technologies LLC | $238K | 1 | | |
| 206 | HSBC HOLDINGS PLC | $232K | 1 | | |
| 207 | NISA INVESTMENT ADVISORS, LLC | $225K | 1 | | |
| 208 | Corient Private Wealth LLC | $222K | 1 | | |
| 209 | CWM, LLC | $216K | 1 | | |
| 210 | VIRTUS ADVISERS, LLC | $203K | 1 | | |
| 211 | BNP Paribas Asset Management Holding S.A. | $128K | 1 | | |
| 212 | FIFTH THIRD BANCORP | $128K | 1 | | |
| 213 | Advisors Asset Management, Inc. | $110K | 1 | | |
| 214 | ASSETMARK, INC | $109K | 1 | | |
| 215 | QUADRANT CAPITAL GROUP LLC | $108K | 1 | | |
| 216 | US BANCORP \DE\ | $95.4K | 1 | | |
| 217 | Allworth Financial LP | $83.5K | 1 | | |
| 218 | Eurizon Capital SGR S.p.A. | $76.4K | 1 | | |
| 219 | Caitong International Asset Management Co., Ltd | $72.9K | 1 | | |
| 220 | Kemnay Advisory Services Inc. | $68.6K | 1 | | |
| 221 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | $61.2K | 1 | | |
| 222 | Pinnacle Wealth Planning Services, Inc. | $51.7K | 1 | | |
| 223 | BAUPOST GROUP LLC/MA | $46.5K | 1 | | |
| 224 | Smartleaf Asset Management LLC | $31.6K | 1 | | |
| 225 | NOMURA ASSET MANAGEMENT CO LTD | $27.9K | 1 | | |
| 226 | Blue Trust, Inc. | $27.3K | 1 | | |
| 227 | CALDWELL SUTTER CAPITAL, INC. | $25.1K | 1 | | |
| 228 | Westside Investment Management, Inc. | $24.2K | 1 | | |
| 229 | Mitsubishi UFJ Asset Management Co., Ltd. | $21.6K | 1 | | |
| 230 | ALGERT GLOBAL LLC | $21.2K | 1 | | |
| 231 | Bayforest Capital Ltd | $20.2K | 1 | | |
| 232 | Optiver Holding B.V. | $17.3K | 1 | | |
| 233 | Owl Creek Wealth Partners LLC | $16.0K | 1 | | |
| 234 | FINANCIAL CONSULATE, INC | $14.5K | 1 | | |
| 235 | E Fund Management (Hong Kong) Co., Ltd. | $14.1K | 1 | | |
| 236 | DANSKE BANK A/S | $11.6K | 1 | | |
| 237 | Private Wealth Management Group, LLC | $11.4K | 1 | | |
| 238 | C WorldWide Group Holding A/S | $11.3K | 1 | | |
| 239 | Federation des caisses Desjardins du Quebec | $11.2K | 1 | | |
| 240 | West Branch Capital LLC | $7.8K | 1 | | |
| 241 | MEEDER ASSET MANAGEMENT INC | $7.7K | 1 | | |
| 242 | Leonteq Securities AG | $6.4K | 1 | | |
| 243 | Parkside Financial Bank & Trust | $6.1K | 1 | | |
| 244 | Arax Advisory Partners | $6.0K | 1 | | |
| 245 | MCF Advisors LLC | $5.6K | 1 | | |
| 246 | Larson Financial Group LLC | $5.5K | 1 | | |
| 247 | Physician Wealth Advisors, Inc. | $5.5K | 1 | | |
| 248 | Bell Investment Advisors, Inc | $4.9K | 1 | | |
| 249 | ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ | $4.5K | 1 | | |
| 250 | HRT FINANCIAL LP | $2.2K | 1 | | |
| 251 | Johnson Financial Group, Inc. | $1.9K | 1 | | |
| 252 | Keating Financial Advisory Services, Inc. | $1.9K | 1 | | |
| 253 | Transamerica Financial Advisors, LLC | $1.8K | 1 | | |
| 254 | MAI Capital Management | $1.7K | 1 | | |
| 255 | First Pacific Financial | $1.5K | 1 | | |
| 256 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $1.5K | 1 | | |
| 257 | Atlantic Edge Private Wealth Management, LLC | $1.5K | 1 | | |
| 258 | Aster Capital Management (DIFC) Ltd | $1.4K | 1 | | |
| 259 | DekaBank Deutsche Girozentrale | $1.2K | 1 | | |
| 260 | PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | $815 | 1 | | |
| 261 | CANADA LIFE ASSURANCE Co | $782 | 1 | | |
| 262 | THRIVENT FINANCIAL FOR LUTHERANS | $682 | 1 | | |
| 263 | Godfrey Financial Associates, Inc. | $349 | 1 | | |
| 264 | JPL Wealth Management, LLC | $291 | 1 | | |
| 265 | Virtu Financial LLC | $257 | 1 | | |
| 266 | Quantitative Investment Management, LLC | $238 | 1 | | |
| 267 | Rachor Investment Advisory Services, LLC | $233 | 1 | | |
| 268 | KBC Group NV | $227 | 1 | | |
| 269 | AMALGAMATED BANK | $209 | 1 | | |
| 270 | Tradewinds Capital Management, LLC | $117 | 1 | | |
| 271 | Cassaday & Co Wealth Management LLC | $117 | 1 | | |
| 272 | ACADIAN ASSET MANAGEMENT LLC | $62 | 1 | | |
| 273 | American Capital Advisory, LLC | $59 | 1 | | |
| 274 | Capital Advisors, Ltd. LLC | $58 | 1 | | |
| 275 | SBI Securities Co., Ltd. | $58 | 1 | | |
| 276 | Rakuten Securities, Inc. | $58 | 1 | | |
| 277 | Avion Wealth | $2 | 1 | | |
| 278 | VANGUARD GROUP INC | $0 | 1 | | |
| 279 | HARBOUR INVESTMENTS, INC. | $0 | 1 | | |
| 280 | Clearstead Advisors, LLC | $0 | 1 | | |
| 281 | COMERICA BANK | $0 | 1 | | |
| 282 | MACKENZIE FINANCIAL CORP | $0 | 1 | | |
| 283 | GROUP ONE TRADING LLC | $0 | 1 | | |
| 284 | HARBOR CAPITAL ADVISORS, INC. | $0 | 1 | | |
| 285 | CIBC WORLD MARKETS CORP | $0 | 1 | | |
| 286 | TANG CAPITAL MANAGEMENT LLC | $0 | 1 | | |
| 287 | CIBC Private Wealth Group LLC | $0 | 1 | | |
| 288 | NORGES BANK | $0 | 1 | | |
| 289 | CITADEL ADVISORS LLC | $0 | 1 | | |
| 290 | TWO SIGMA SECURITIES, LLC | $0 | 1 | | |
| 291 | Verition Fund Management LLC | $0 | 1 | | |
| 292 | Alberta Investment Management Corp | $0 | 1 | | |
| 293 | SIMPLEX TRADING, LLC | $0 | 1 | | |
| 294 | Quantbot Technologies LP | $0 | 1 | | |
| 295 | EcoR1 Capital, LLC | $0 | 1 | | |
| 296 | Neo Ivy Capital Management | $0 | 1 | | |
| 297 | Global Retirement Partners, LLC | $0 | 1 | | |
| 298 | Qsemble Capital Management, LP | $0 | 1 | | |
| 299 | Aquatic Capital Management LLC | $0 | 1 | | |
| 300 | INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | $0 | 1 | | |
| 301 | AlphaQuest LLC | $0 | 1 | | |
| 302 | SageView Advisory Group, LLC | $0 | 1 | | |
| 303 | Dunhill Financial, LLC | $0 | 1 | | |
| 304 | Perbak Capital Partners LLP | $0 | 1 | | |
| 305 | Turning Point Benefit Group, Inc. | $0 | 1 | | |