TCG Crossover Management, LLC

CIK 1839948 · EDGAR ↗
sum of disclosed values for 2026-03-31; 0 positions have no disclosed value and are left out of the sum, counted here rather than dropped
$3.5B
every reported holding for this filer and quarter, including ones with no disclosed value
49
positions with no comparable holding in the prior quarter (kind new), 2026-03-31
11
positions absent from this quarter's filing after being held last quarter (kind exit), 2026-03-31 — inferred from absence, not a sale record
5
Quarter-end snapshot, filed up to 45 days later — not current holdings. What a 13F covers ↓
FILING WINDOW OPEN
Q3 2026 filings are due by 2026-11-16 — figures for that quarter will change; missing filers are not zeros.

Changes · Quarter ended 2026-03-31. Newest filing in this build: 2026-07-31. Per-row filing dates are on each receipt.

by shares · How classified ↗
Period
Position changes into quarter 2026-03-31
position matched across quarters by exact reported CUSIP over a registry gap — never a name matchNEW / ADD / TRIM / EXIT by share count · NO CHANGE = same shares; the value moved with price, so never an ADD or a TRIM · EXIT = absent this quarter (disposed, delisted, confidential, or reported by an affiliate) — the filing does not say which · NO PRIOR = no comparable prior quarter on record (a first filing, or a quarter filed inside an affiliate's report), so not called a new stake · n/c = not classifiable: value undisclosed on one side of the pair, or neither shares nor value can classify it · †v: the reported share count is unchanged across the pair; this build's data classified the change from its reported value; builds from 2026-09-10 on read it as NO CHANGEderived by Public Filings from the published data; “no value” means the source did not disclose a usable value — never zeroreported unit changed across the pair (SH↔PRN); the share delta is withheld rather than fabricatedPrev valueCurr valuePrev sharesCurr shares
share class as filed: ADRS · position key pos:12364 · issuer key iss:26TRIM−$237M−630,511$959M$722M7,111,5966,481,085
share class as filed: COMM · position key pos:11535 · issuer key iss:1757TRIM+$107M−2,231,023$113M$220M12,762,09410,531,071
share class as filed: COMM · position key pos:17421 · issuer key iss:475TRIM−$18.0M−921,268$208M$190M5,868,1624,946,894
share class as filed: COMM · position key sid:sec:prov:47170149b82e95e4444c881acffa67fc · issuer key cusip6:90240BADD+$48.2M+350,877$76.2M$124M2,898,1033,248,980
share class as filed: COMM · position key sid:sec:prov:c0680e314bfe2d1131f5c3d642c67920 · issuer key cusip6:45258JADD+$68.5M+2,797,055$42.2M$111M1,660,9334,457,988
share class as filed: COMM · position key pos:15075 · issuer key iss:265NEW+$105M+11,020,968$0$105M—11,020,968
share class as filed: COMM · position key pos:11504 · issuer key iss:1236ADD+$93.2M+1,000,000$4.9M$98.1M62,0491,062,049
share class as filed: COMM · position key sid:sec:prov:60242973181bde6041719c13381cdbb1 · issuer key cusip6:929033NEW+$96.5M+5,673,078$0$96.5M—5,673,078
share class as filed: COMM · position key pos:12161 · issuer key iss:587NEW+$85.8M+1,341,862$0$85.8M—1,341,862
share class as filed: COMM · position key pos:14656 · issuer key iss:1552ADD+$21.3M+140,000$34.8M$56.1M436,473576,473
share class as filed: COMM · position key sid:sec:prov:be515631054470e2500985b7cc1d1245 · issuer key cusip6:50180MADD+$6.4M+94,474$38.8M$45.3M1,745,0151,839,489
share class as filed: COMM · position key sid:sec:prov:0d3c6673b7060f8873ebd8344c73bee8 · issuer key cusip6:86889PNEW+$42.9M+1,473,101$0$42.9M—1,473,101
share class as filed: COMM · position key pos:12369 · issuer key iss:1540ADD+$15.3M+1,053,170$27.2M$42.5M3,220,1864,273,356
share class as filed: COMM · position key sid:sec:prov:310355a827423f86fff2dece8e909dcb · issuer key cusip6:15673TNEW+$39.0M+17,754,430$0$39.0M—17,754,430
share class as filed: COMM · position key sid:sec:prov:ab98bdc5d9f0946c8554aa4745533ba5 · issuer key cusip6:878972NEW+$37.2M+1,204,891$0$37.2M—1,204,891
share class as filed: COMM · position key sid:sec:prov:5732a7abafb10622c73486c8e76bb0b0 · issuer key cusip6:46489VNEW+$33.0M+7,915,567$0$33.0M—7,915,567
share class as filed: COMM · position key pos:10657 · issuer key iss:667ADD+$7.4M+199,108$21.5M$28.9M2,088,3922,287,500
share class as filed: COMM · position key sid:sec:prov:cfab5f07b0b6fc7e17744bf457f942d7 · issuer key cusip6:00166BNEW+$26.1M+13,011,849$0$26.1M—13,011,849
share class as filed: COMM · position key pos:11358 · issuer key iss:173TRIM−$6.3M−278,755$31.6M$25.3M2,666,2162,387,461
share class as filed: ADRS · position key sid:sec:prov:fb9ea7ee3bb27d4ceeeb748915397758 · issuer key cusip6:00860CNEW+$21.5M+2,053,233$0$21.5M—2,053,233
share class as filed: COMM · position key pos:14778 · issuer key iss:1131TRIM−$43.8M−1,307,036$59.0M$15.2M1,710,084403,048
share class as filed: COMM · position key sid:sec:prov:26fd673c04b9acd4e799cbdab734d215 · issuer key cusip6:67576ATRIM−$55.7M−4,092,479$69.7M$14.0M5,740,2311,647,752
share class as filed: COMM · position key sid:sec:prov:37b91915f07af95197894a79df85a91e · issuer key cusip6:05338FADD+$2.3M+255,383$8.8M$11.0M483,000738,383
share class as filed: COMM · position key sid:sec:prov:a469da6cabfc03832e3d85a7bff09e97 · issuer key cusip6:M96088TRIM−$9.5M−311,982$16.8M$7.3M717,347405,365
share class as filed: COMM · position key sid:sec:prov:8416c67ffd3651f6a5f8d9788c0f2e31 · issuer key cusip6:61023LTRIM−$2.0M−9,812$9.3M$7.2M141,915132,103
share class as filed: COMM · position key sid:sec:prov:1e37f227d26a900c417273e355bd6875 · issuer key cusip6:21077PNEW+$7.0M+2,682,696$0$7.0M—2,682,696
share class as filed: ADRS · position key sid:sec:prov:862b191ccb923fc424f39385b48ce4f8 · issuer key cusip6:86366ETRIM−$57.3M−780,446$64.0M$6.8M920,857140,411
share class as filed: COMM · position key pos:12625 · issuer key iss:544NEW+$5.8M+406,786$0$5.8M—406,786
share class as filed: COMM · position key sid:sec:prov:1e348df3cde91ba41d5ebeef0c53e107 · issuer key cusip6:91678ATRIM−$18.6M−562,823$20.2M$1.6M743,886181,063
pos:13165EXIT‡e−$32.2M−1,181,841$32.2M$01,181,841—
pos:15345EXIT‡e−$7.2M−173,816$7.2M$0173,816—
sid:sec:prov:0983c227d7f489fadce1abda0a417532EXIT‡e−$87.5M−2,582,408$87.5M$02,582,408—
sid:sec:prov:0e361d30324f107464e8c1d4734fc7e8EXIT‡e−$2.9M−316,195$2.9M$0316,195—
sid:sec:prov:dcfd7178444c2349b987cfc50b6bf1d8EXIT‡e−$65.3M−3,572,335$65.3M$03,572,335—

Ticker: no position here maps to a reviewed ticker. Flags: no row carries a flag.

1–20 of the 34 changes on this page

Mark-to-market only (no share change) · 20

Positions whose share count is identical in both quarters; the value changed with price, not with a decision.

Positions held with no share change into quarter 2026-03-31
position matched across quarters by exact reported CUSIP over a registry gap — never a name matchNEW / ADD / TRIM / EXIT by share count · NO CHANGE = same shares; the value moved with price, so never an ADD or a TRIM · EXIT = absent this quarter (disposed, delisted, confidential, or reported by an affiliate) — the filing does not say which · NO PRIOR = no comparable prior quarter on record (a first filing, or a quarter filed inside an affiliate's report), so not called a new stake · n/c = not classifiable: value undisclosed on one side of the pair, or neither shares nor value can classify it · †v: the reported share count is unchanged across the pair; this build's data classified the change from its reported value; builds from 2026-09-10 on read it as NO CHANGEderived by Public Filings from the published data; “no value” means the source did not disclose a usable value — never zeroreported unit changed across the pair (SH↔PRN); the share delta is withheld rather than fabricatedPrev valueCurr valuePrev sharesCurr shares
share class as filed: COMM · position key pos:11549 · issuer key iss:429NO CHANGE+$96.0M0$152M$248M3,670,2063,670,206
share class as filed: ADRS · position key pos:17964 · issuer key iss:2365NO CHANGE+$63.1M0$107M$170M4,286,4804,286,480
share class as filed: COMM · position key pos:17547 · issuer key iss:577NO CHANGE+$71.6M0$69.1M$141M1,676,6241,676,624
share class as filed: COMM · position key pos:13625 · issuer key iss:45NO CHANGE+$33.6M0$62.3M$95.9M1,900,5821,900,582
share class as filed: COMM · position key sid:sec:prov:6456a8a739b1b376bb8de72f440b1279 · issuer key cusip6:03237HNO CHANGE+$11.4M0$75.4M$86.8M6,243,8126,243,812
share class as filed: COMM · position key pos:13703 · issuer key iss:619NO CHANGE−$6.6M0$90.3M$83.7M4,615,1444,615,144
share class as filed: COMM · position key sid:sec:prov:3224bd4d4c1e7dd823e99e6304f866c2 · issuer key cusip6:61225MNO CHANGE+$3.6M0$72.5M$76.0M4,622,1514,622,151
share class as filed: COMM · position key sid:sec:prov:2bc6a25d40cf07124e3a03bdecf4a4df · issuer key cusip6:805111NO CHANGE−$7.0M0$74.5M$67.5M12,362,20512,362,205
share class as filed: COMM · position key sid:sec:prov:b6301632224d8122ae8dff0115962cfa · issuer key cusip6:50015MNO CHANGE+$14.7M0$40.4M$55.1M1,445,5381,445,538
share class as filed: COMM · position key sid:sec:prov:8da00f0cae7aab2e87fae6f0ec349fcf · issuer key cusip6:H0036KNO CHANGE+$2.5M0$40.2M$42.7M11,390,17511,390,175
share class as filed: COMM · position key sid:sec:prov:b66dc0816f9158ee3c706ae6f74ba1a4 · issuer key cusip6:359616NO CHANGE−$19.1M0$59.4M$40.3M5,250,0005,250,000
share class as filed: COMM · position key pos:13686 · issuer key iss:2049NO CHANGE−$13.1M0$52.3M$39.2M4,631,3174,631,317
share class as filed: COMM · position key sid:sec:prov:bc17a1945987420f684d9107b41fd336 · issuer key cusip6:98401FNO CHANGE−$8.0M0$37.5M$29.6M2,452,1382,452,138
share class as filed: COMM · position key sid:sec:prov:7f79da9ff584753bfd1b9acc24c00236 · issuer key cusip6:47103JNO CHANGE+$179K0$24.7M$24.9M1,789,6171,789,617
share class as filed: COMM · position key sid:sec:prov:1c7c81831d7de024bffc2474a53ee4b9 · issuer key cusip6:014442NO CHANGE+$5.9M0$15.6M$21.5M10,000,00010,000,000
share class as filed: COMM · position key sid:sec:prov:1910147dd0682cb840152de5838d5484 · issuer key cusip6:55287LNO CHANGE−$1.1M0$20.5M$19.4M650,000650,000
share class as filed: ADRS · position key sid:sec:prov:5c7f5b7b9166fb5eb65582ad9f6aefb9 · issuer key cusip6:82686QNO CHANGE−$2.5M0$18.4M$16.0M3,033,5603,033,560
share class as filed: COMM · position key sid:sec:prov:32df3091b0447927d2680841e51efc1f · issuer key cusip6:500946NO CHANGE+$1.4M0$3.3M$4.7M416,301416,301
share class as filed: COMM · position key sid:sec:prov:b4fb61062116268ce297ca59ebf42283 · issuer key cusip6:04746LNO CHANGE+$1.3M0$3.3M$4.7M464,398464,398
share class as filed: COMM · position key sid:sec:prov:ab6da773af8f9d90bd90fe82cc6dbcd7 · issuer key cusip6:92840HNO CHANGE−$242K0$1.8M$1.5M2,676,5802,676,580

Ticker: no position here maps to a reviewed ticker. Flags: no row carries a flag.

Holdings without a security ID are counted, not compared. Method ↗

Reported positions — 2026-03-31

49 positions
View
This build carries one quarter for this manager: 2026-03-31. Notable managers carry four published quarters, others two.
Every row below carries ticker not yet mapped — stated once here rather than repeated on every row.
Positions TCG Crossover Management, LLC reported for the quarter ended 2026-03-31, as that filer reported them
a position composed from a base filing plus NEW-HOLDINGS amendments keeps every source row here; the composition's latest filed date is the one shown served from this build's published holdings (derived from the filer's own reported rows); every row resolves to its filingShare of total reported value, calculated only when the full position list has disclosed values. This is 13F long value, not total assets.value undisclosed on the filing: retained and counted, excluded from sums, never shown as $0SharesWt
ABIVAX SA AMERICAN DEPOSITARY SHARES · ADRS CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$722M6,481,08520.6%
CG ONCOLOGY INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$248M3,670,2067.1%
TANGO THERAPEUTICS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$220M10,531,0716.3%
COGENT BIOSCIENCES INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$190M4,946,8945.4%
CENTESSA PHARMACEUTICALS PLC · ADRS CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$170M4,286,4804.9%
DIANTHUS THERAPEUTICS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$141M1,676,6244.0%
TYRA BIOSCIENCES INC · COMM CUSIP 90240B106
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$124M3,248,9803.6%
IMMUNOVANT INC · COMM CUSIP 45258J102
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$111M4,457,9883.2%
BIOCRYST PHARMACEUTICALS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$105M11,020,9683.0%
MIRUM PHARMACEUTICALS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$98.1M1,062,0492.8%
VOR BIOPHARMA INC · COMM CUSIP 929033207
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$96.5M5,673,0782.8%
SPYRE THERAPEUTICS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$95.9M1,900,5822.7%
AMYLYX PHARMACEUTICALS INC · COMM CUSIP 03237H101
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$86.8M6,243,8122.5%
DISC MEDICINE INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$85.8M1,341,8622.5%
DYNE THERAPEUTICS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$83.7M4,615,1442.4%
MONTE ROSA THERAPEUTICS INC · COMM CUSIP 61225M102
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$76.0M4,622,1512.2%
SAVARA INC · COMM CUSIP 805111101
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$67.5M12,362,2051.9%
REVOLUTION MEDICINES INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$56.1M576,4731.6%
KODIAK SCIENCES INC · COMM CUSIP 50015M109
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$55.1M1,445,5381.6%
LB PHARMACEUTICALS INC · COMM CUSIP 50180M108
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$45.3M1,839,4891.3%
SURROZEN INC · COMM CUSIP 86889P208
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$42.9M1,473,1011.2%
ADC THERAPEUTICS SA · COMM CUSIP H0036K147
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$42.7M11,390,1751.2%
RELAY THERAPEUTICS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$42.5M4,273,3561.2%
FULCRUM THERAPEUTICS INC · COMM CUSIP 359616109
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$40.3M5,250,0001.2%
BIOHAVEN LTD · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$39.2M4,631,3171.1%
CENTURY THERAPEUTICS INC · COMM CUSIP 15673T100
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$39.0M17,754,4301.1%
TECTONIC THERAPEUTIC INC · COMM CUSIP 878972108
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$37.2M1,204,8911.1%
PERSPECTIVE THERAPEUTICS INC · COMM CUSIP 46489V302
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$33.0M7,915,5670.9%
XENCOR INC · COMM CUSIP 98401F105
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$29.6M2,452,1380.8%
ENTRADA THERAPEUTICS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$28.9M2,287,5000.8%
ALX ONCOLOGY HOLDINGS INC · COMM CUSIP 00166B105
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$26.1M13,011,8490.7%
ARVINAS HOLDING CO LLC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$25.3M2,387,4610.7%
JANUX THERAPEUTICS INC · COMM CUSIP 47103J105
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$24.9M1,789,6170.7%
AGOMAB THERAPEUTICS NV · ADRS CUSIP 00860C102
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$21.5M2,053,2330.6%
ALECTOR INC · COMM CUSIP 014442107
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$21.5M10,000,0000.6%
MBX BIOSCIENCES INC · COMM CUSIP 55287L101
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$19.4M650,0000.6%
SILENCE THERAPEUTICS PLC · ADRS CUSIP 82686Q101
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$16.0M3,033,5600.5%
LIQUIDIA TECHNOLOGIES INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$15.2M403,0480.4%
OCULAR THERAPEUTIX INC · COMM CUSIP 67576A100
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$14.0M1,647,7520.4%
AVALO THERAPEUTICS INC · COMM CUSIP 05338F306
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$11.0M738,3830.3%
UROGEN PHARMA LTD · COMM CUSIP M96088105
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$7.3M405,3650.2%
MONOPAR THERAPEUTICS INC · COMM CUSIP 61023L207
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$7.2M132,1030.2%
CONTEXT THERAPEUTICS INC · COMM CUSIP 21077P108
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$7.0M2,682,6960.2%
STRUCTURE THERAPEUTICS INC · ADRS CUSIP 86366E106
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$6.8M140,4110.2%
CULLINAN THERAPEUTICS INC · COMM CUSIP —
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$5.8M406,7860.2%
KORRO BIO INC · COMM CUSIP 500946108
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$4.7M416,3010.1%
LEONABIO INC · COMM CUSIP 04746L203
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$4.7M464,3980.1%
UPSTREAM BIO INC · COMM CUSIP 91678A107
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$1.6M181,0630.0%
VISTAGEN THERAPEUTICS INC · COMM CUSIP 92840H400
quarter ended 2026-03-31 filed filed 2026-05-15 +45d
$1.5M2,676,5800.0%

1–20 of 49 positions

Ticker: no reported row here maps to a reviewed ticker.

1–49 of 49 positions · page 1 of 1
One line per issuer, largest first — open a line for its reported rows. Grouping ↗

Book shape

Tick = median of the 8,748 tracked filers with a 2026-03-31 book (the index median: the 8,662 with a complete book). Concentration uses reported 13F long value, not total assets; the index is withheld when any position lacks a value.
share of the period's disclosed value held in the top-N positions; denominator is reported 13F value, not total assets
88.3%above median 80.0%
integer Herfindahl–Hirschman index in basis points over disclosed position values
689 bpsabove median 446 bps
holdings with no disclosed value (undisclosed, or unreadable on the filing) — kept and counted, never shown as zero
49 / 49median book 97.5 positions

54 quarter-over-quarter rows

Filing history

Available filing periods
PeriodSource
2026-03-31EDGAR ↗
Complete source filings on SEC EDGAR

The filing on EDGAR is the record, including any filed after this build.

Open TCG Crossover Management, LLC's 13F filings on SEC EDGAR ↗
A 13F is a quarterly, long-only snapshot filed up to 45 days late — not current holdings. what a 13F covers ↗

13F reports cover LONG positions in Section 13(f) securities (US exchange-traded equities plus reportable options, warrants, certain convertibles) held by managers with at least $100M in such securities — so managers below that threshold are absent entirely. No short positions, no cash, no non-13(f) assets — not a full portfolio, and not a census of institutional ownership.

Positions are quarter-end snapshots filed up to 45 days late — not current holdings: a position may have changed or closed since the quarter ended.

Values are the manager's stated market value at quarter-end in era-dependent units (whole dollars for form versions effective 2023-01-03 onward, thousands before), normalized here to whole dollars; each record notes its original unit.

Affiliated managers may report the same position, so one position can appear under more than one filer.

Positions under confidential treatment may be omitted until a later amendment discloses them.

These are disclosures, not investment advice.