RTW INVESTMENTS, LP

CIK 1493215 · EDGAR ↗

sum of disclosed values for 2026-03-31; 0 positions have no disclosed value and are left out of the sum, counted here rather than dropped: $10.0B
every reported holding for this filer and quarter, including ones with no disclosed value: 88
positions with no comparable holding in the prior quarter (kind new), 2026-03-31: 9
positions absent from this quarter's filing after being held last quarter (kind exit), 2026-03-31 — inferred from absence, not a sale record: 12

Quarter-end snapshot, filed up to 45 days later — not current holdings. What a 13F covers ↓

Changes · Quarter ended 2026-03-31. Newest filing in this build: 2026-07-31. Per-row filing dates are on each receipt.

Position changes into quarter 2026-03-31
The reviewed ticker for the filed issuer name and share class, the same mapping the Reported positions table uses. Symbols are never inferred from names; — means no reviewed mapping.	position matched across quarters by exact reported CUSIP over a registry gap — never a name match	NEW / ADD / TRIM / EXIT by share count · NO CHANGE = same shares; the value moved with price, so never an ADD or a TRIM · EXIT = absent this quarter (disposed, delisted, confidential, or reported by an affiliate) — the filing does not say which · NO PRIOR = no comparable prior quarter on record (a first filing, or a quarter filed inside an affiliate's report), so not called a new stake · n/c = not classifiable: value undisclosed on one side of the pair, or neither shares nor value can classify it · †v: the reported share count is unchanged across the pair; this build's data classified the change from its reported value; builds from 2026-09-10 on read it as NO CHANGE	derived by Public Filings from the published data; “no value” means the source did not disclose a usable value — never zero	reported unit changed across the pair (SH↔PRN); the share delta is withheld rather than fabricated	Prev value	Curr value	Prev shares	Curr shares
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM PAR $.01 · position key `pos:14207` · issuer key `iss:973`	ADD	−$50.9M	+1	$843M	$792M	4,842,879	4,842,880
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: SPONSORED ADR · position key `pos:17260` · issuer key `iss:165`	ADD	−$48.3M	+35,949	$566M	$518M	673,497	709,446
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:11549` · issuer key `iss:429`	ADD	+$389M	+4,972,681	$83.5M	$473M	2,012,127	6,984,808
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:10390` · issuer key `iss:416`	ADD	+$292M	+2,489,461	$54.9M	$347M	550,160	3,039,621
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:11535` · issuer key `iss:1757`	ADD	+$265M	+11,809,392	$13.2M	$278M	1,491,228	13,300,620
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:11747` · issuer key `iss:680`	ADD	+$261M	+16,010,524	$546K	$261M	146,651	16,157,175
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:13186` · issuer key `iss:1273`	TRIM	−$93.6M	−250,000	$344M	$250M	1,500,000	1,250,000
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:11138` · issuer key `iss:1519`	ADD	−$41.5M	+346,500	$281M	$239M	3,938,500	4,285,000
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:10610` · issuer key `iss:1761`	ADD	−$38.4M	+10,705	$273M	$235M	3,335,320	3,346,025
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:13239` · issuer key `iss:142`	ADD	+$29.5M	+70,000	$205M	$234M	2,712,097	2,782,097
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:17421` · issuer key `iss:475`	TRIM	−$59.6M	−2,133,566	$270M	$210M	7,592,241	5,458,675
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12344` · issuer key `iss:946`	ADD	−$12.8M	+486,510	$210M	$197M	1,181,990	1,668,500
—	share class as filed: COM · position key `sid:sec:prov:3fee4169345e05a49cf14bcc2babfc71` · issuer key `cusip6:86150R`	ADD	+$7.0M	+76,669	$176M	$183M	5,546,856	5,623,525
—	share class as filed: COM · position key `sid:sec:prov:7bf59fd7aeffb1ecf2ffdacd97c7e39d` · issuer key `cusip6:G31249`	ADD	−$37.9M	+66,864	$189M	$151M	2,588,831	2,655,695
—	share class as filed: COM · position key `sid:sec:prov:233302be8852a126d4f3dc726082a4c4` · issuer key `cusip6:03753U`	TRIM	−$44.3M	−3,981,719	$193M	$148M	7,666,764	3,685,045
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12597` · issuer key `iss:1545`	ADD	−$32.3M	+142,000	$174M	$142M	1,064,000	1,206,000
—	share class as filed: SHS · position key `sid:sec:prov:8771e17f16590b5bd511978f2a4f7807` · issuer key `cusip6:N44445`	ADD	+$6.6M	+1,435,986	$120M	$127M	11,433,354	12,869,340
—	share class as filed: ADR · position key `pos:13828` · issuer key `iss:2487`	TRIM	+$900K	−385,000	$123M	$124M	6,959,032	6,574,032
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM NEW · position key `pos:16805` · issuer key `iss:997`	ADD	+$44.1M	+118,772	$57.3M	$101M	101,228	220,000
—	share class as filed: SPONSORED ADS · position key `pos:17964` · issuer key `iss:2365`	ADD	+$36.8M	+263,338	$44.8M	$81.6M	1,790,837	2,054,175

Flags: no row carries a flag.

1–20 of the 64 changes on this page

Mark-to-market only (no share change) · 36

Positions whose share count is identical in both quarters; the value changed with price, not with a decision.

Positions held with no share change into quarter 2026-03-31
The reviewed ticker for the filed issuer name and share class, the same mapping the Reported positions table uses. Symbols are never inferred from names; — means no reviewed mapping.	position matched across quarters by exact reported CUSIP over a registry gap — never a name match	NEW / ADD / TRIM / EXIT by share count · NO CHANGE = same shares; the value moved with price, so never an ADD or a TRIM · EXIT = absent this quarter (disposed, delisted, confidential, or reported by an affiliate) — the filing does not say which · NO PRIOR = no comparable prior quarter on record (a first filing, or a quarter filed inside an affiliate's report), so not called a new stake · n/c = not classifiable: value undisclosed on one side of the pair, or neither shares nor value can classify it · †v: the reported share count is unchanged across the pair; this build's data classified the change from its reported value; builds from 2026-09-10 on read it as NO CHANGE	derived by Public Filings from the published data; “no value” means the source did not disclose a usable value — never zero	Prev value	Curr value	Prev shares	Curr shares
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:14357` · issuer key `iss:1170`	NO CHANGE	−$117M	$1.2B	$1.0B	1,993,687	1,993,687
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:13950` · issuer key `iss:1497`	NO CHANGE	+$91.4M	$442M	$533M	5,059,053	5,059,053
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:17611` · issuer key `iss:1399`	NO CHANGE	−$60.7M	$588M	$528M	7,746,415	7,746,415
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM NEW · position key `pos:13625` · issuer key `iss:45`	NO CHANGE	+$73.8M	$137M	$210M	4,171,996	4,171,996
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM NEW · position key `pos:12465` · issuer key `iss:548`	NO CHANGE	+$6.4M	$173M	$179M	2,721,158	2,721,158
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:17971` · issuer key `iss:30`	NO CHANGE	−$31.8M	$191M	$159M	7,144,524	7,144,524
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: ADS · position key `pos:15541` · issuer key `iss:958`	NO CHANGE	−$22.2M	$169M	$147M	4,869,798	4,869,798
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:11462` · issuer key `iss:1296`	NO CHANGE	−$10.7M	$151M	$140M	1,062,072	1,062,072
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:17626` · issuer key `iss:860`	NO CHANGE	−$14.5M	$151M	$137M	1,481,033	1,481,033
—	share class as filed: SPONSORED ADS · position key `sid:sec:prov:831c753eb8a6ce9972092ec4165601d4` · issuer key `cusip6:07782B`	NO CHANGE	−$372K	$114M	$114M	715,332	715,332
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:13812` · issuer key `iss:1378`	NO CHANGE	+$38.6M	$62.4M	$101M	2,058,148	2,058,148
—	share class as filed: ORDINARY SHARES · position key `sid:sec:prov:592cbdfa12c811cc697874a89333d4bb` · issuer key `cusip6:G3855L`	NO CHANGE	+$8.1M	$75.4M	$83.4M	5,933,815	5,933,815
—	share class as filed: COM · position key `sid:sec:prov:bc17a1945987420f684d9107b41fd336` · issuer key `cusip6:98401F`	NO CHANGE	−$22.0M	$104M	$81.7M	6,777,461	6,777,461
—	share class as filed: COM · position key `sid:sec:prov:a469da6cabfc03832e3d85a7bff09e97` · issuer key `cusip6:M96088`	NO CHANGE	−$24.7M	$106M	$81.7M	4,543,895	4,543,895
—	share class as filed: COM · position key `sid:sec:prov:5db085c4e925ed01a4a1cbc6ba09d304` · issuer key `cusip6:77313F`	NO CHANGE	+$1.2M	$62.1M	$63.3M	17,687,772	17,687,772
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: SHS · position key `pos:15525` · issuer key `iss:2023`	NO CHANGE	+$12.3M	$46.8M	$59.1M	1,672,356	1,672,356
—	share class as filed: COM · position key `sid:sec:prov:9f123b52d9dfa5657af06135ef52f112` · issuer key `cusip6:68572M`	NO CHANGE	+$831K	$34.5M	$35.3M	8,306,063	8,306,063
—	share class as filed: COM NEW · position key `pos:13163` · issuer key `iss:2484`	NO CHANGE	−$15.9M	$50.8M	$34.9M	6,576,306	6,576,306
—	share class as filed: COM · position key `sid:sec:prov:2bc6a25d40cf07124e3a03bdecf4a4df` · issuer key `cusip6:805111`	NO CHANGE	−$3.4M	$35.9M	$32.5M	5,952,380	5,952,380
—	share class as filed: COM · position key `sid:sec:prov:2436d0e4b9db5d946b26deb83a717d5e` · issuer key `cusip6:64135M`	NO CHANGE	−$599K	$28.1M	$27.5M	1,362,456	1,362,456
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12625` · issuer key `iss:544`	NO CHANGE	+$6.6M	$17.7M	$24.2M	1,705,960	1,705,960
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12598` · issuer key `iss:1082`	NO CHANGE	+$1.3M	$18.7M	$20.0M	240,000	240,000
—	share class as filed: COM · position key `sid:sec:prov:fbdfb263adbfc86bd605b695db4205d4` · issuer key `cusip6:07373V`	NO CHANGE	−$2.2M	$15.8M	$13.6M	570,394	570,394
—	share class as filed: COM · position key `sid:sec:prov:5c9dafc33c07d8edc9231c0ecacc39e5` · issuer key `cusip6:42238D`	NO CHANGE	−$2.4M	$14.4M	$12.0M	495,000	495,000
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: SHS · position key `pos:14281` · issuer key `iss:2313`	NO CHANGE	−$13.2M	$23.0M	$9.8M	1,350,000	1,350,000
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: CL A ORD SHS · position key `pos:15905` · issuer key `iss:2186`	NO CHANGE	−$1.5M	$9.7M	$8.1M	742,500	742,500
—	share class as filed: COM NEW · position key `sid:sec:prov:f5ab5fc62f8ffc42012ac685dc8651c0` · issuer key `cusip6:14070B`	NO CHANGE	+$385K	$7.2M	$7.6M	250,000	250,000
—	share class as filed: COM · position key `pos:11729` · issuer key `iss:2412`	NO CHANGE	−$3.5M	$11.0M	$7.5M	1,300,000	1,300,000
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:16706` · issuer key `iss:2081`	NO CHANGE	+$2.4M	$4.4M	$6.8M	372,856	372,856
—	share class as filed: COM · position key `sid:sec:prov:9e0f507ae4c750638fbe313997f8baa5` · issuer key `cusip6:550249`	NO CHANGE	−$6.4M	$12.0M	$5.6M	650,000	650,000
—	share class as filed: COM · position key `sid:sec:prov:adc22e9a1524ab89aa68e69a21eb8d93` · issuer key `cusip6:35104E`	NO CHANGE	+$861K	$3.6M	$4.4M	475,737	475,737
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM CL A · position key `pos:15409` · issuer key `iss:1212`	NO CHANGE	+$175K	$2.9M	$3.1M	70,000	70,000
—	share class as filed: COM · position key `sid:sec:prov:748c3ea2043f7dae881221f3c766e002` · issuer key `cusip6:68170A`	NO CHANGE	−$642K	$3.2M	$2.5M	200,000	200,000
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12161` · issuer key `iss:587`	NO CHANGE	−$464K	$2.4M	$1.9M	30,000	30,000
—	share class as filed: COM · position key `sid:sec:prov:6db6b47119928ad4af3cf49015c9c5eb` · issuer key `cusip6:45175G`	NO CHANGE	−$635K	$2.3M	$1.7M	334,445	334,445
—	share class as filed: *W EXP 09/02/202 · position key `sid:sec:prov:2e0b7c193ae04d1491f7555c4c197a31` · issuer key `cusip6:77313F`	NO CHANGE	−$1.3K	$8.5K	$7.2K	350,000	350,000

Flags: no row carries a flag.

Holdings without a security ID are counted, not compared. Method ↗

Reported positions — 2026-03-31

87 issuers · 88 rows

View

This build carries one quarter for this manager: 2026-03-31. Notable managers carry four published quarters, others two.

This list carries reported issuer names and security identities, without a dated ticker mapping. Symbols are not inferred from names.

a position composed from a base filing plus NEW-HOLDINGS amendments keeps every source row here; the composition's latest filed date is the one shown served from this build's published holdings (derived from the filer's own reported rows); every row resolves to its filing

Share of total reported value, calculated only when the full position list has disclosed values. This is 13F long value, not total assets.

value undisclosed on the filing: retained and counted, excluded from sums, never shown as $0

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

MADRIGAL PHARMACEUTICALS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$1.0B

1,993,687

10.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

INSMED INC · COM PAR $.01 CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$792M

4,842,880

7.9%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

PROTAGONIST THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$533M

5,059,053

5.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

PTC THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$528M

7,746,415

5.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ARGENX SE · SPONSORED ADR CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$518M

709,446

5.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CG ONCOLOGY INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$473M

6,984,808

4.7%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CELCUITY INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$347M

3,039,621

3.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

TANGO THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$278M

13,300,620

2.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ERASCA INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$261M

16,157,175

2.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

NATERA INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$250M

1,250,000

2.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

RADNET INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$239M

4,285,000

2.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

TARSUS PHARMACEUTICALS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$235M

3,346,025

2.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

APOGEE THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$234M

2,782,097

2.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

SPYRE THERAPEUTICS INC · COM NEW CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$210M

4,171,996

2.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

COGENT BIOSCIENCES INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$210M

5,458,675

2.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

IRHYTHM HOLDINGS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$197M

1,668,500

2.0%

—

STOKE THERAPEUTICS INC · COM CUSIP 86150R107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$183M

5,623,525

1.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CYTOKINETICS INC · COM NEW CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$179M

2,721,158

1.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ACADIA PHARMACEUTICALS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$159M

7,144,524

1.6%

—

ESTABLISHMENT LABS HLDGS INC · COM CUSIP G31249108
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$151M

2,655,695

1.5%

—

APELLIS PHARMACEUTICALS INC · COM CUSIP 03753U106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$148M

3,685,045

1.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

IMMUNOCORE HLDGS PLC · ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$147M

4,869,798

1.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

REPLIGEN CORP · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$142M

1,206,000

1.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

NEUROCRINE BIOSCIENCES INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$140M

1,062,072

1.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

GUARDANT HEALTH INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$137M

1,481,033

1.4%

—

IMMATICS N.V · SHS CUSIP N44445109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$127M

12,869,340

1.3%

—

ZAI LAB LTD · ADR CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$124M

6,574,032

1.2%

—

BELITE BIO INC · SPONSORED ADS CUSIP 07782B104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$114M

715,332

1.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

INTUITIVE SURGICAL INC · COM NEW CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$101M

220,000

1.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ORUKA THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$101M

2,058,148

1.0%

—

GH RESEARCH PLC · ORDINARY SHARES CUSIP G3855L106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$83.4M

5,933,815

0.8%

—

XENCOR INC · COM CUSIP 98401F105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$81.7M

6,777,461

0.8%

—

UROGEN PHARMA LTD · COM CUSIP M96088105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$81.7M

4,543,895

0.8%

—

CENTESSA PHARMACEUTICALS PLC · SPONSORED ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$81.6M

2,054,175

0.8%

—

IMMUNOVANT INC · COM CUSIP 45258J102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$78.9M

3,177,849

0.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ULTRAGENYX PHARMACEUTICAL IN · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$76.4M

3,648,795

0.8%

—

HINGE HEALTH INC · CL A CUSIP 433313103
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$74.4M

1,930,000

0.7%

—

CASTLE BIOSCIENCES INC · COM CUSIP 14843C105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$67.7M

2,758,335

0.7%

—

ROCKET PHARMACEUTICALS INC

2 positions · 2 reported rows

Rows RTW INVESTMENTS, LP reported for ROCKET PHARMACEUTICALS INC, as it reported them
ROCKET PHARMACEUTICALS INC · COM CUSIP 77313F106 src ↗	$63.3M	17,687,772
ROCKET PHARMACEUTICALS INC · *W EXP 09/02/202 CUSIP 77313F114 src ↗	$7.2K	350,000

ticker not yet mapped

$63.3M

18,037,772

0.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

TAYSHA GENE THERAPIES INC · COM SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$61.2M

13,680,248

0.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ALKERMES PLC · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$59.1M

1,672,356

0.6%

—

COMPASS PATHWAYS PLC · SPONSORED ADS CUSIP 20451W101
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$58.8M

10,632,390

0.6%

—

KODIAK SCIENCES INC · COM CUSIP 50015M109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$56.7M

1,487,934

0.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

REPLIMUNE GROUP INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$56.3M

7,356,916

0.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CRINETICS PHARMACEUTICALS IN · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$52.7M

1,451,326

0.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

UNIQURE NV · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$42.3M

2,586,356

0.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

WAYSTAR HLDG CORP · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$39.3M

1,630,000

0.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ARROWHEAD PHARMACEUTICALS IN · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$36.7M

585,682

0.4%

—

ORCHESTRA BIOMED HLDGS INC · COM CUSIP 68572M106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$35.3M

8,306,063

0.4%

—

VERASTEM INC · COM NEW CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$34.9M

6,576,306

0.3%

—

EVOMMUNE INC · COM SHS CUSIP 30054Y107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$34.5M

1,502,235

0.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

STRYKER CORPORATION · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$32.9M

100,000

0.3%

—

SAVARA INC · COM CUSIP 805111101
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$32.5M

5,952,380

0.3%

—

CANDEL THERAPEUTICS INC · COM CUSIP 137404109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$31.5M

6,422,018

0.3%

—

AQUESTIVE THERAPEUTICS INC · COM CUSIP 03843E104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$30.8M

7,426,471

0.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

AKTIS ONCOLOGY INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$28.5M

1,592,043

0.3%

—

NEUROGENE INC · COM CUSIP 64135M105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$27.5M

1,362,456

0.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CULLINAN THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$24.2M

1,705,960

0.2%

—

COMPASS THERAPEUTICS INC · COM CUSIP 20454B104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$22.1M

4,186,599

0.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

DIANTHUS THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$20.8M

248,063

0.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

FULGENT GENETICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$20.5M

1,289,000

0.2%

—

BETA BIONICS INC · COM CUSIP 08659B102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$20.0M

2,000,000

0.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

KYMERA THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$20.0M

240,000

0.2%

—

CENTURY THERAPEUTICS INC · COM CUSIP 15673T100
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$19.7M

8,695,652

0.2%

—

BEAM THERAPEUTICS INC · COM CUSIP 07373V105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$13.6M

570,394

0.1%

—

AVALO THERAPEUTICS INC · COM NEW CUSIP 05338F306
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$12.8M

856,962

0.1%

—

OCUGEN INC · COM CUSIP 67577C105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$12.1M

6,666,666

0.1%

—

HEARTFLOW INC · COM CUSIP 42238D107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$12.0M

495,000

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

WAVE LIFE SCIENCES LTD · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$9.8M

1,350,000

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

PERCEPTIVE CAP SOLUTIONS COR · CL A ORD SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$8.1M

742,500

0.1%

—

JADE BIOSCIENCES INC · COM NEW CUSIP 008064206
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$8.1M

573,205

0.1%

—

CAPRICOR THERAPEUTICS INC · COM NEW CUSIP 14070B309
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.6M

250,000

0.1%

—

MILESTONE PHARMACEUTICALS IN · COM CUSIP 59935V107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.5M

6,331,001

0.1%

—

KALARIS THERAPEUTICS INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.5M

1,300,000

0.1%

—

INVENTIVA SA · ADS CUSIP 46124U107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.2M

1,298,702

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ATAIBECKLEY INC · COM SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$7.1M

2,000,000

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

CRESCENT BIOPHARMA INC. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$6.8M

372,856

0.1%

—

LARIMAR THERAPEUTICS INC · COM CUSIP 517125100
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$6.8M

1,500,000

0.1%

—

TENAX THERAPEUTICS INC · COM NEW CUSIP 88032L605
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$5.9M

370,246

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

DEFINIUM THERAPEUTICS INC · COM SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$5.7M

300,000

0.1%

—

LUMEXA IMAGING HOLDINGS INC · COM CUSIP 550249106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$5.6M

650,000

0.1%

—

4D MOLECULAR THERAPEUTICS IN · COM CUSIP 35104E100
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$4.4M

475,737

0.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

MEDLINE INC · COM CL A CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$3.1M

70,000

0.0%

—

OMADA HEALTH INC · COM CUSIP 68170A108
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$2.5M

200,000

0.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

DISC MEDICINE INC · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$1.9M

30,000

0.0%

—

IMAGENEBIO INC · COM CUSIP 45175G207
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$1.7M

334,445

0.0%

—

EXAGEN INC · COM CUSIP 30068X103
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$1.2M

395,231

0.0%

1–20 of 87 issuers

One line per issuer, largest first — open a line for its reported rows. Grouping ↗

Book shape

Tick = median of the 8,748 tracked filers with a 2026-03-31 book (the index median: the 8,662 with a complete book). Concentration uses reported 13F long value, not total assets; the index is withheld when any position lacks a value.

share of the period's disclosed value held in the top-N positions; denominator is reported 13F value, not total assets: 77.0%below median 80.0%
integer Herfindahl–Hirschman index in basis points over disclosed position values: 372 bpsbelow median 446 bps
holdings with no disclosed value (undisclosed, or unreadable on the filing) — kept and counted, never shown as zero: 88 / 88median book 97.5 positions

100 quarter-over-quarter rows

Filing history

Available filing periods
Period	Source
2026-03-31	EDGAR ↗

Complete source filings on SEC EDGAR

The filing on EDGAR is the record, including any filed after this build.

Open RTW INVESTMENTS, LP's 13F filings on SEC EDGAR ↗

A 13F is a quarterly, long-only snapshot filed up to 45 days late — not current holdings. what a 13F covers ↗

13F reports cover LONG positions in Section 13(f) securities (US exchange-traded equities plus reportable options, warrants, certain convertibles) held by managers with at least $100M in such securities — so managers below that threshold are absent entirely. No short positions, no cash, no non-13(f) assets — not a full portfolio, and not a census of institutional ownership.

Positions are quarter-end snapshots filed up to 45 days late — not current holdings: a position may have changed or closed since the quarter ended.

Values are the manager's stated market value at quarter-end in era-dependent units (whole dollars for form versions effective 2023-01-03 onward, thousands before), normalized here to whole dollars; each record notes its original unit.

Affiliated managers may report the same position, so one position can appear under more than one filer.

Positions under confidential treatment may be omitted until a later amendment discloses them.

These are disclosures, not investment advice.

Changes · Q1 2026Quarter ended 2026-03-31. Newest filing in this build: 2026-07-31. Per-row filing dates are on each receipt.

Reported positions — 2026-03-31

Book shape

Filing history

Changes · Quarter ended 2026-03-31. Newest filing in this build: 2026-07-31. Per-row filing dates are on each receipt.