BAKER BROS. ADVISORS LP

CIK 1263508 · EDGAR ↗

sum of disclosed values for 2026-03-31; 0 positions have no disclosed value and are left out of the sum, counted here rather than dropped: $17.4B
every reported holding for this filer and quarter, including ones with no disclosed value: 84
positions with no comparable holding in the prior quarter (kind new), 2026-03-31: 7
positions absent from this quarter's filing after being held last quarter (kind exit), 2026-03-31 — inferred from absence, not a sale record: 9

Quarter-end snapshot, filed up to 45 days later — not current holdings. What a 13F covers ↓

Changes · Quarter ended 2026-03-31. Newest filing in this build: 2026-07-31. Per-row filing dates are on each receipt.

Position changes into quarter 2026-03-31
The reviewed ticker for the filed issuer name and share class, the same mapping the Reported positions table uses. Symbols are never inferred from names; — means no reviewed mapping.	position matched across quarters by exact reported CUSIP over a registry gap — never a name match	NEW / ADD / TRIM / EXIT by share count · NO CHANGE = same shares; the value moved with price, so never an ADD or a TRIM · EXIT = absent this quarter (disposed, delisted, confidential, or reported by an affiliate) — the filing does not say which · NO PRIOR = no comparable prior quarter on record (a first filing, or a quarter filed inside an affiliate's report), so not called a new stake · n/c = not classifiable: value undisclosed on one side of the pair, or neither shares nor value can classify it · †v: the reported share count is unchanged across the pair; this build's data classified the change from its reported value; builds from 2026-09-10 on read it as NO CHANGE	derived by Public Filings from the published data; “no value” means the source did not disclose a usable value — never zero	reported unit changed across the pair (SH↔PRN); the share delta is withheld rather than fabricated	Prev value	Curr value	Prev shares	Curr shares	Flags
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:15877` · issuer key `iss:961`	ADD	−$143M	+421	$3.0B	$2.9B	30,743,991	30,744,412
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM PAR $.01 · position key `pos:14207` · issuer key `iss:973`	ADD	+$66.1M	+828,365	$1.1B	$1.2B	6,592,746	7,421,111
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:14656` · issuer key `iss:1552`	ADD	+$176M	+100,000	$753M	$929M	9,455,357	9,555,357
—	share class as filed: COM · position key `pos:11142` · issuer key `iss:1475`	ADD	+$233M	+626,710	$332M	$565M	1,126,488	1,753,198
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12631` · issuer key `iss:843`	ADD	+$29.7M	+1,943,281	$178M	$208M	2,085,333	4,028,614
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:11517` · issuer key `iss:1003`	ADD	+$12.0M	+255,886	$142M	$154M	1,791,841	2,047,727
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: SHS · position key `pos:17657` · issuer key `iss:2200`	TRIM	+$14.3M	−687,294	$121M	$135M	5,555,017	4,867,723
—	share class as filed: COM · position key `sid:sec:prov:f7d48a640772d3aa60939ca4949078c5` · issuer key `cusip6:45166A`	ADD	+$6.4M	+327,689	$125M	$131M	3,618,826	3,946,515
—	share class as filed: COM · position key `pos:15725` · issuer key `iss:172`	TRIM	−$19.5M	−182,862	$144M	$125M	2,175,645	1,992,783
—	share class as filed: SHS · position key `sid:sec:prov:8771e17f16590b5bd511978f2a4f7807` · issuer key `cusip6:N44445`	TRIM	−$19.6M	−1,177,401	$127M	$107M	12,094,094	10,916,693
—	share class as filed: COM · position key `sid:sec:prov:1bcf5245eb051e3018a085f3acbfd157` · issuer key `cusip6:00288U`	ADD	+$11.5M	+2,750,298	$94.1M	$106M	27,525,640	30,275,938
—	share class as filed: COM · position key `pos:14981` · issuer key `iss:535`	ADD	+$8.7M	+702,596	$76.8M	$85.4M	1,648,869	2,351,465
—	share class as filed: Note 2.75% 8/1/2031 · position key `pos:15366` · issuer key `iss:416`	n/c‡u	+$8.3M	—	$66.6M	$74.9M	30,750,000	30,750,000	change n/cunit mismatch
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:17547` · issuer key `iss:577`	ADD	+$39.0M	+62,405	$32.5M	$71.5M	789,759	852,164
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:16159` · issuer key `iss:94`	ADD	+$29.1M	+450,000	$15.3M	$44.3M	1,562,500	2,012,500
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:11504` · issuer key `iss:1236`	NEW	+$41.2M	+445,975	$0	$41.2M	—	445,975
—	share class as filed: COM · position key `sid:sec:prov:bf437640b37b30ed62d091e5e9de5808` · issuer key `cusip6:29337E`	ADD	+$31.3M	+633,785	$4.2M	$35.5M	271,406	905,191
—	share class as filed: COM · position key `sid:sec:prov:652160e4f88d5e68e96c8504db5fee2d` · issuer key `cusip6:25056L`	ADD	+$6.6M	+352,879	$20.9M	$27.5M	2,233,099	2,585,978
—	share class as filed: COM · position key `sid:sec:prov:16b2967c1b0bb76b6346bfde109e0bb6` · issuer key `cusip6:23284F`	ADD	+$5.3M	+725,000	$18.1M	$23.4M	4,250,826	4,975,826
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12161` · issuer key `iss:587`	ADD	−$4.4M	+12,607	$26.8M	$22.4M	337,050	349,657

1–20 of the 41 changes on this page

Mark-to-market only (no share change) · 52

Positions whose share count is identical in both quarters; the value changed with price, not with a decision.

Positions held with no share change into quarter 2026-03-31
The reviewed ticker for the filed issuer name and share class, the same mapping the Reported positions table uses. Symbols are never inferred from names; — means no reviewed mapping.	position matched across quarters by exact reported CUSIP over a registry gap — never a name match	NEW / ADD / TRIM / EXIT by share count · NO CHANGE = same shares; the value moved with price, so never an ADD or a TRIM · EXIT = absent this quarter (disposed, delisted, confidential, or reported by an affiliate) — the filing does not say which · NO PRIOR = no comparable prior quarter on record (a first filing, or a quarter filed inside an affiliate's report), so not called a new stake · n/c = not classifiable: value undisclosed on one side of the pair, or neither shares nor value can classify it · †v: the reported share count is unchanged across the pair; this build's data classified the change from its reported value; builds from 2026-09-10 on read it as NO CHANGE	derived by Public Filings from the published data; “no value” means the source did not disclose a usable value — never zero	Prev value	Curr value	Prev shares	Curr shares
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: SPONSORED ADS · position key `pos:14374` · issuer key `iss:248`	NO CHANGE	−$60.2M	$2.7B	$2.6B	8,799,053	8,799,053
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:14357` · issuer key `iss:1170`	NO CHANGE	−$126M	$1.2B	$1.1B	2,141,701	2,141,701
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:17971` · issuer key `iss:30`	NO CHANGE	−$191M	$1.1B	$955M	42,896,690	42,896,690
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:10390` · issuer key `iss:416`	NO CHANGE	+$114M	$790M	$904M	7,915,792	7,915,792
—	share class as filed: COM · position key `sid:sec:prov:b6301632224d8122ae8dff0115962cfa` · issuer key `cusip6:50015M`	NO CHANGE	+$202M	$557M	$759M	19,919,186	19,919,186
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12598` · issuer key `iss:1082`	NO CHANGE	+$47.4M	$674M	$721M	8,657,242	8,657,242
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12361` · issuer key `iss:1727`	NO CHANGE	+$53.5M	$636M	$690M	36,391,063	36,391,063
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:16702` · issuer key `iss:1556`	NO CHANGE	−$112M	$600M	$487M	5,604,483	5,604,483
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: SHS · position key `pos:15525` · issuer key `iss:2023`	NO CHANGE	+$73.9M	$280M	$354M	10,012,267	10,012,267
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:11808` · issuer key `iss:635`	NO CHANGE	+$44.0M	$163M	$207M	6,575,940	6,575,940
—	share class as filed: ORD SHS CL A · position key `pos:13344` · issuer key `iss:2148`	NO CHANGE	+$19.5M	$117M	$136M	2,826,246	2,826,246
—	share class as filed: COM · position key `sid:sec:prov:c0680e314bfe2d1131f5c3d642c67920` · issuer key `cusip6:45258J`	NO CHANGE	−$3.2M	$139M	$136M	5,457,881	5,457,881
—	share class as filed: COM · position key `sid:sec:prov:3fee4169345e05a49cf14bcc2babfc71` · issuer key `cusip6:86150R`	NO CHANGE	+$2.7M	$106M	$109M	3,336,697	3,336,697
—	share class as filed: SPONSORED ADS · position key `pos:12364` · issuer key `iss:26`	NO CHANGE	−$20.6M	$118M	$97.5M	875,796	875,796
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12518` · issuer key `iss:1547`	NO CHANGE	−$22.9M	$107M	$84.5M	11,045,336	11,045,336
—	share class as filed: COM · position key `sid:sec:prov:48ac0f50c981e01f7c5af17d58a117cf` · issuer key `cusip6:67080M`	NO CHANGE	−$16.2M	$88.4M	$72.2M	4,658,556	4,658,556
—	share class as filed: COM · position key `sid:sec:prov:8948595df4e56c28a2e8dffed59ee810` · issuer key `cusip6:24823R`	NO CHANGE	+$10.0M	$61.6M	$71.6M	3,731,695	3,731,695
—	share class as filed: COM · position key `sid:sec:prov:3224bd4d4c1e7dd823e99e6304f866c2` · issuer key `cusip6:61225M`	NO CHANGE	+$3.3M	$68.1M	$71.5M	4,345,736	4,345,736
—	share class as filed: SPONSORED ADS · position key `sid:sec:prov:862b191ccb923fc424f39385b48ce4f8` · issuer key `cusip6:86366E`	NO CHANGE	−$30.6M	$99.6M	$69.0M	1,432,529	1,432,529
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:10657` · issuer key `iss:667`	NO CHANGE	+$11.9M	$52.1M	$64.0M	5,072,730	5,072,730
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: SPONSORED ADS · position key `pos:16739` · issuer key `iss:260`	NO CHANGE	−$26.6M	$77.1M	$50.5M	10,885,357	10,885,357
—	share class as filed: COM · position key `pos:13625` · issuer key `iss:45`	NO CHANGE	+$17.7M	$32.8M	$50.4M	1,000,000	1,000,000
—	share class as filed: COM · position key `sid:sec:prov:9fd554b76cc510ac236cd887d1f06195` · issuer key `cusip6:75383L`	NO CHANGE	+$1.5M	$46.9M	$48.4M	1,547,090	1,547,090
—	share class as filed: COM · position key `sid:sec:prov:4b145c10f034612809a5ead021971789` · issuer key `cusip6:92790C`	NO CHANGE	−$22.8M	$61.4M	$38.6M	1,971,678	1,971,678
—	share class as filed: COM · position key `sid:sec:prov:52a86e73e5ebd8fb9104a71a48f9c42d` · issuer key `cusip6:74065P`	NO CHANGE	+$5.3M	$29.4M	$34.6M	10,123,824	10,123,824
—	share class as filed: SPONSORED ADS · position key `sid:sec:prov:097fe4205cdb81b5acf642533490216f` · issuer key `cusip6:23306J`	NO CHANGE	+$2.5M	$28.0M	$30.5M	1,461,425	1,461,425
—	share class as filed: SPONSORED ADS · position key `pos:17964` · issuer key `iss:2365`	NO CHANGE	+$9.9M	$16.8M	$26.6M	670,751	670,751
—	share class as filed: COM · position key `sid:sec:prov:3b4a08cf659449a1ac1d2ee41e501b50` · issuer key `cusip6:008064`	NO CHANGE	−$2.3M	$25.3M	$23.1M	1,641,137	1,641,137
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12517` · issuer key `iss:1997`	NO CHANGE	+$4.9M	$16.6M	$21.5M	370,208	370,208
—	share class as filed: COM · position key `sid:sec:prov:30f8f229420c7a82ec2ecf2f2f622045` · issuer key `cusip6:15117B`	NO CHANGE	+$3.0M	$18.1M	$21.1M	665,370	665,370
—	share class as filed: COM · position key `sid:sec:prov:2436d0e4b9db5d946b26deb83a717d5e` · issuer key `cusip6:64135M`	NO CHANGE	−$436K	$20.4M	$20.0M	991,691	991,691
—	share class as filed: CL A · position key `sid:sec:prov:05537d56ca21ce3a27a9a933baf06b09` · issuer key `cusip6:21217B`	NO CHANGE	+$2.3M	$16.2M	$18.6M	1,420,838	1,420,838
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: SPONSORED ADR · position key `pos:17260` · issuer key `iss:165`	NO CHANGE	−$2.8M	$21.2M	$18.4M	25,174	25,174
—	share class as filed: COM · position key `sid:sec:prov:5acb3fdf8cac3eec6cd20dcb98ac92d0` · issuer key `cusip6:157085`	NO CHANGE	−$2.4M	$20.6M	$18.2M	10,008,345	10,008,345
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM SHS · position key `pos:13793` · issuer key `iss:1763`	NO CHANGE	−$4.1M	$22.0M	$17.9M	4,004,756	4,004,756
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:10212` · issuer key `iss:1665`	NO CHANGE	−$420K	$16.5M	$16.0M	400,000	400,000
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:13703` · issuer key `iss:619`	NO CHANGE	−$1.2M	$15.9M	$14.7M	813,449	813,449
—	share class as filed: COM · position key `sid:sec:prov:bc17a1945987420f684d9107b41fd336` · issuer key `cusip6:98401F`	NO CHANGE	−$3.6M	$16.9M	$13.3M	1,102,106	1,102,106
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:12369` · issuer key `iss:1540`	NO CHANGE	+$1.7M	$9.8M	$11.5M	1,160,117	1,160,117
—	share class as filed: CLASS A COM · position key `sid:sec:prov:6af2a0bf15f867d1bff8c7930f134308` · issuer key `cusip6:81749D`	NO CHANGE	−$5.1M	$16.2M	$11.2M	5,498,170	5,498,170
a reviewed mapping row for this filed issuer name and share class (never inferred from the name)	share class as filed: COM · position key `pos:14578` · issuer key `iss:2296`	NO CHANGE	+$188K	$10.4M	$10.6M	375,000	375,000
—	share class as filed: COM · position key `sid:sec:prov:25db868bd92949401541405f5298734d` · issuer key `cusip6:56565P`	NO CHANGE	+$1.0M	$6.4M	$7.4M	364,705	364,705
—	share class as filed: COM · position key `sid:sec:prov:f3f8f36b088f3feb965b6e5cad32a6e3` · issuer key `cusip6:00091E`	NO CHANGE	−$1.0M	$7.5M	$6.4M	2,134,803	2,134,803
—	share class as filed: CL A · position key `sid:sec:prov:d870181e4209250aa4f0822ee5192029` · issuer key `cusip6:918385`	NO CHANGE	−$48.9K	$5.9M	$5.9M	148,314	148,314
—	share class as filed: COM STK · position key `sid:sec:prov:f702a4fd275ccf1ac7ea45ff5986f07c` · issuer key `cusip6:74365U`	NO CHANGE	−$117K	$5.2M	$5.1M	971,614	971,614
—	share class as filed: COM SER A · position key `sid:sec:prov:5e2abdcbdb056fb4d049308ad37d5f46` · issuer key `cusip6:786700`	NO CHANGE	−$662K	$5.6M	$5.0M	952,996	952,996
—	share class as filed: COM SHS · position key `sid:sec:prov:be515631054470e2500985b7cc1d1245` · issuer key `cusip6:50180M`	NO CHANGE	+$480K	$4.5M	$4.9M	200,000	200,000
—	share class as filed: COM · position key `sid:sec:prov:39d93878365e006cfbf0af4c0560d7f2` · issuer key `cusip6:89854M`	NO CHANGE	+$27.8K	$2.8M	$2.8M	2,784,792	2,784,792
—	share class as filed: COM · position key `sid:sec:prov:7ff2ed7cd5581a47f16a78be72caca7a` · issuer key `cusip6:799566`	NO CHANGE	−$369K	$1.3M	$894K	310,483	310,483
—	share class as filed: COM · position key `sid:sec:prov:c8979a8455f9af85be7efdcf54e29bb5` · issuer key `cusip6:01626L`	NO CHANGE	−$157K	$774K	$617K	83,055	83,055
—	share class as filed: COM · position key `sid:sec:prov:47170149b82e95e4444c881acffa67fc` · issuer key `cusip6:90240B`	NO CHANGE	+$127K	$279K	$406K	10,607	10,607
—	share class as filed: W EXP 8/11/2026 · position key `sid:sec:prov:c4f97db1890f36f80c7a359d19822318` · issuer key `cusip6:86889P`	NO CHANGE	−$3.3K	$16.7K	$13.3K	833,333	833,333

Flags: no row carries a flag.

Holdings without a security ID are counted, not compared. Method ↗

Reported positions — 2026-03-31

83 issuers · 84 rows

View

This build carries one quarter for this manager: 2026-03-31. Notable managers carry four published quarters, others two.

This list carries reported issuer names and security identities, without a dated ticker mapping. Symbols are not inferred from names.

a position composed from a base filing plus NEW-HOLDINGS amendments keeps every source row here; the composition's latest filed date is the one shown served from this build's published holdings (derived from the filer's own reported rows); every row resolves to its filing

Share of total reported value, calculated only when the full position list has disclosed values. This is 13F long value, not total assets.

value undisclosed on the filing: retained and counted, excluded from sums, never shown as $0

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Incyte Corporation · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$2.9B

30,744,412

16.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

BeOne Medicines Ltd. · SPONSORED ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$2.6B

8,799,053

15.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Insmed Incorporated · COM PAR $.01 CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$1.2B

7,421,111

7.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Madrigal Pharmaceuticals, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$1.1B

2,141,701

6.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Celcuity Inc.

2 positions · 2 reported rows

Rows BAKER BROS. ADVISORS LP reported for Celcuity Inc., as it reported them
Celcuity Inc. · COM CUSIP — src ↗	$904M	7,915,792
Celcuity Inc. · Note 2.75% 8/1/2031 CUSIP — src ↗	$74.9M	30,750,000

$978M

38,665,792

5.6%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

ACADIA Pharmaceuticals Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$955M

42,896,690

5.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Revolution Medicines, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$929M

9,555,357

5.3%

—

Kodiak Sciences Inc. · COM CUSIP 50015M109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$759M

19,919,186

4.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Kymera Therapeutics, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$721M

8,657,242

4.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Summit Therapeutics Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$690M

36,391,063

4.0%

—

Praxis Precision Medicines, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$565M

1,753,198

3.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Rhythm Pharmaceuticals, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$487M

5,604,483

2.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Alkermes plc · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$354M

10,012,267

2.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

GRAIL, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$208M

4,028,614

1.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Edgewise Therapeutics, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$207M

6,575,940

1.2%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Ionis Pharmaceuticals, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$154M

2,047,727

0.9%

—

Kiniksa Pharmaceuticals International, plc · ORD SHS CL A CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$136M

2,826,246

0.8%

—

Immunovant, Inc. · COM CUSIP 45258J102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$136M

5,457,881

0.8%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Roivant Sciences Ltd. · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$135M

4,867,723

0.8%

—

IDEAYA Biosciences, Inc. · COM CUSIP 45166A102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$131M

3,946,515

0.8%

—

Arrowhead Pharmaceuticals, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$125M

1,992,783

0.7%

—

Stoke Therapeutics, Inc. · COM CUSIP 86150R107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$109M

3,336,697

0.6%

—

Immatics N.V. · SHS CUSIP N44445109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$107M

10,916,693

0.6%

—

AbCellera Biologics Inc. · COM CUSIP 00288U106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$106M

30,275,938

0.6%

—

Abivax S.A. · SPONSORED ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$97.5M

875,796

0.6%

—

Crinetics Pharmaceuticals, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$85.4M

2,351,465

0.5%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Replimune Group, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$84.5M

11,045,336

0.5%

—

Nurix Therapeutics, Inc. · COM CUSIP 67080M103
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$72.2M

4,658,556

0.4%

—

Denali Therapeutics Inc. · COM CUSIP 24823R105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$71.6M

3,731,695

0.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Dianthus Therapeutics, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$71.5M

852,164

0.4%

—

Monte Rosa Therapeutics, Inc. · COM CUSIP 61225M102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$71.5M

4,345,736

0.4%

—

Structure Therapeutics Inc. · SPONSORED ADS CUSIP 86366E106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$69.0M

1,432,529

0.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Entrada Therapeutics, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$64.0M

5,072,730

0.4%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Bicycle Therapeutics plc · SPONSORED ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$50.5M

10,885,357

0.3%

—

Spyre Therapeutics, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$50.4M

1,000,000

0.3%

—

Rapport Therapeutics, Inc. · COM CUSIP 75383L102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$48.4M

1,547,090

0.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Alumis Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$44.3M

2,012,500

0.3%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Mirum Pharmaceuticals, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$41.2M

445,975

0.2%

—

Viridian Therapeutics, Inc. · COM CUSIP 92790C104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$38.6M

1,971,678

0.2%

—

Enliven Therapeutics, Inc. · COM CUSIP 29337E102
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$35.5M

905,191

0.2%

—

Prelude Therapeutics Inc. · COM CUSIP 74065P101
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$34.6M

10,123,824

0.2%

—

DBV Technologies S.A. · SPONSORED ADS CUSIP 23306J309
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$30.5M

1,461,425

0.2%

—

Design Therapeutics, Inc. · COM CUSIP 25056L103
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$27.5M

2,585,978

0.2%

—

Centessa Pharmaceuticals plc · SPONSORED ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$26.6M

670,751

0.2%

—

CytomX Therapeutics, Inc. · COM CUSIP 23284F105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$23.4M

4,975,826

0.1%

—

Jade Biosciences, Inc. · COM CUSIP 008064206
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$23.1M

1,641,137

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Disc Medicine, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$22.4M

349,657

0.1%

—

Immunocore Holdings plc · ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$22.1M

734,397

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Xenon Pharmaceuticals Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$21.5M

370,208

0.1%

—

Celldex Therapeutics, Inc. · COM CUSIP 15117B202
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$21.1M

665,370

0.1%

—

Neurogene Inc. · COM CUSIP 64135M105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$20.0M

991,691

0.1%

—

Evommune, Inc. · COM SHS CUSIP 30054Y107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$19.5M

847,390

0.1%

—

Tectonic Therapeutic, Inc. · COM CUSIP 878972108
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$18.8M

607,788

0.1%

—

Contineum Therapeutics, Inc. · CL A CUSIP 21217B100
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$18.6M

1,420,838

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

argenx SE · SPONSORED ADR CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$18.4M

25,174

0.1%

—

Cerus Corporation · COM CUSIP 157085101
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$18.2M

10,008,345

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Taysha Gene Therapies, Inc. · COM SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$17.9M

4,004,756

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Aktis Oncology, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$17.8M

996,351

0.1%

—

Generate Biomedicines, Inc. · COM SHS CUSIP 370920100
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$17.8M

1,423,602

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Sionna Therapeutics, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$16.0M

400,000

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Dyne Therapeutics, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$14.7M

813,449

0.1%

—

Xencor, Inc. · COM CUSIP 98401F105
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$13.3M

1,102,106

0.1%

—

COMPASS Pathways plc · SPONSORED ADS CUSIP 20451W101
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$13.0M

2,344,720

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Relay Therapeutics, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$11.5M

1,160,117

0.1%

—

Sera Prognostics, Inc. · CLASS A COM CUSIP 81749D107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$11.2M

5,498,170

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

BioNTech SE · SPONSORED ADS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$10.6M

119,743

0.1%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Pharvaris N.V. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$10.6M

375,000

0.1%

—

Arcus Biosciences, Inc. · COM CUSIP 03969F109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$9.0M

415,621

0.1%

—

MapLight Therapeutics, Inc. · COM CUSIP 56565P103
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$7.4M

364,705

0.0%

—

Absci Corporation · COM CUSIP 00091E109
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$6.4M

2,134,803

0.0%

verified against the SEC company list on 2026-09-10 — a reviewed mapping row for this filed issuer name and class (never inferred)

Wave Life Sciences Ltd. · SHS CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

$6.0M

822,638

0.0%

—

vTv Therapeutics, Inc. · CL A CUSIP 918385204
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$5.9M

148,314

0.0%

—

Eikon Therapeutics, Inc. · COM CUSIP 282564103
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$5.9M

555,555

0.0%

—

Protara Therapeutics, Inc. · COM STK CUSIP 74365U107
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$5.1M

971,614

0.0%

—

Sagimet Biosciences Inc. · COM SER A CUSIP 786700104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$5.0M

952,996

0.0%

—

LB Pharmaceuticals Inc. · COM SHS CUSIP 50180M108
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$4.9M

200,000

0.0%

—

Verastem, Inc. · COM CUSIP —
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$3.1M

584,757

0.0%

—

TScan Therapeutics, Inc. · COM CUSIP 89854M101
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$2.8M

2,784,792

0.0%

—

Skye Bioscience, Inc. · COM CUSIP 83086J200
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$968K

1,575,243

0.0%

—

Sana Biotechnology, Inc. · COM CUSIP 799566104
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$894K

310,483

0.0%

—

Aligos Therapeutics, Inc. · COM CUSIP 01626L204
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$617K

83,055

0.0%

—

Tyra Biosciences, Inc. · COM CUSIP 90240B106
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$406K

10,607

0.0%

—

Surrozen, Inc. · W EXP 8/11/2026 CUSIP 86889P117
2026-03-31 filed 2026-05-15 +45d

src ↗

ticker not yet mapped

$13.3K

833,333

0.0%

1–20 of 83 issuers

One line per issuer, largest first — open a line for its reported rows. Grouping ↗

Book shape

Tick = median of the 8,748 tracked filers with a 2026-03-31 book (the index median: the 8,662 with a complete book). Concentration uses reported 13F long value, not total assets; the index is withheld when any position lacks a value.

share of the period's disclosed value held in the top-N positions; denominator is reported 13F value, not total assets: 91.0%above median 80.0%
integer Herfindahl–Hirschman index in basis points over disclosed position values: 761 bpsabove median 446 bps
holdings with no disclosed value (undisclosed, or unreadable on the filing) — kept and counted, never shown as zero: 84 / 84median book 97.5 positions

93 quarter-over-quarter rows

Filing history

Available filing periods
Period	Source
2026-03-31	EDGAR ↗

Complete source filings on SEC EDGAR

The filing on EDGAR is the record, including any filed after this build.

Open BAKER BROS. ADVISORS LP's 13F filings on SEC EDGAR ↗

A 13F is a quarterly, long-only snapshot filed up to 45 days late — not current holdings. what a 13F covers ↗

13F reports cover LONG positions in Section 13(f) securities (US exchange-traded equities plus reportable options, warrants, certain convertibles) held by managers with at least $100M in such securities — so managers below that threshold are absent entirely. No short positions, no cash, no non-13(f) assets — not a full portfolio, and not a census of institutional ownership.

Positions are quarter-end snapshots filed up to 45 days late — not current holdings: a position may have changed or closed since the quarter ended.

Values are the manager's stated market value at quarter-end in era-dependent units (whole dollars for form versions effective 2023-01-03 onward, thousands before), normalized here to whole dollars; each record notes its original unit.

Affiliated managers may report the same position, so one position can appear under more than one filer.

Positions under confidential treatment may be omitted until a later amendment discloses them.

These are disclosures, not investment advice.

Changes · Q1 2026Quarter ended 2026-03-31. Newest filing in this build: 2026-07-31. Per-row filing dates are on each receipt.

Reported positions — 2026-03-31

Book shape

Filing history

Changes · Quarter ended 2026-03-31. Newest filing in this build: 2026-07-31. Per-row filing dates are on each receipt.